Resolve to Save Lives (RTSL) is a nonprofit global health organization focused on preventing deaths from cardiovascular disease (CVD) and epidemics. Founded in 2017 by Dr. Tom Frieden, RTSL became an independent entity in 2022. The organization operates in the U.S., India, Ethiopia, and Nigeria, supported by major philanthropic partners like Bloomberg Philanthropies and the Bill & Melinda Gates Foundation.

RTSL implements evidence-based strategies primarily in low- and middle-income countries. Its key initiatives include reducing CVD deaths through high blood pressure control, salt reduction, and eliminating trans fats. The organization also developed the 7-1-7 target to enhance epidemic response, which is utilized by various countries and endorsed by the World Health Organization. Additionally, RTSL promotes healthier food policies to improve cardiovascular health outcomes. By collaborating with governments and public health agencies, RTSL aims to save lives and strengthen health systems globally.