The Pontifical Mission Societies in the U.S. (TPMS-USA) is a Catholic missionary organization focused on fostering a universal missionary spirit through prayer, sacrifice, and financial support for the Church's mission worldwide. Founded as part of the global Pontifical Mission Societies in 1822, TPMS-USA operates under the Pope's jurisdiction and collaborates with local bishops and churches to ensure resources are equitably distributed to mission territories.

TPMS-USA provides essential humanitarian aid, including food, education, pastoral care, and medical assistance to vulnerable communities. The organization consists of four societies, each with a specific focus: the Society for the Propagation of the Faith, the Society of St. Peter the Apostle, the Missionary Childhood Association, and the Missionary Union of Priests and Religious. They also utilize digital platforms like Missio.org to connect donors with mission projects, promoting transparent giving. The organization encourages participation from the Catholic faithful across the U.S. through various outreach efforts, including parish programs and annual collections.