drugstore.com was an early online retailer that specialized in health, beauty, skincare, and vision care products. Founded in 1998, it launched its web operations in 1999, aiming to provide a wide selection of wellness products that traditional drugstores could not offer. The company quickly gained popularity, reaching over one million customers in its first year and attracting millions of weekly visitors by 2000.

The company offered around 60,000 non-prescription products and operated multiple branded storefronts, including Beauty.com and SkinStore.com. It provided pharmacy services in partnership with BioScrip Pharmacy Services and had a notable collaboration with Rite Aid, allowing customers to pick up prescriptions at Rite Aid locations. In 2011, drugstore.com was acquired by Walgreens, which integrated its online business into its broader retail strategy. The website was officially shut down in 2016 as Walgreens refocused on its own digital platforms.